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  2. Renal compensation - Wikipedia

    en.wikipedia.org/wiki/Renal_compensation

    Renal compensation is a mechanism by which the kidneys can regulate the plasma pH. It is slower than respiratory compensation, but has a greater ability to restore normal values. Kidneys maintain the acid-base balance through two mechanisms: (1) the secretion of H + ions into the urine (from the blood) and (2) the reabsorption of bicarbonate ...

  3. Renal physiology - Wikipedia

    en.wikipedia.org/wiki/Renal_physiology

    The body is very sensitive to its pH. Outside the range of pH that is compatible with life, proteins are denatured and digested, enzymes lose their ability to function, and the body is unable to sustain itself. The kidneys maintain acid-base homeostasis by regulating the pH of the blood plasma. Gains and losses of acid and base must be balanced.

  4. Acid–base homeostasis - Wikipedia

    en.wikipedia.org/wiki/Acid–base_homeostasis

    This principle is exploited to regulate the pH of the extracellular fluids (rather than just buffering the pH). For the carbonic acid-bicarbonate buffer , a molar ratio of weak acid to weak base of 1:20 produces a pH of 7.4; and vice versa—when the pH of the extracellular fluids is 7.4 then the ratio of carbonic acid to bicarbonate ions in ...

  5. Bicarbonate buffer system - Wikipedia

    en.wikipedia.org/wiki/Bicarbonate_buffer_system

    The pH of tears shift throughout a waking day, rising "about 0.013 pH units/hour" until a prolonged closed-eye period causes the pH to fall again. [15] Most healthy individuals have tear pH in the range of 7.0 to 7.7, where bicarbonate buffering is the most significant, but proteins and other buffering components are also present that are ...

  6. Mammalian kidney - Wikipedia

    en.wikipedia.org/wiki/Mammalian_kidney

    The regulation of the acid-base balance through the bicarbonate buffer system is provided by the lungs and kidneys. [148] The lungs regulate CO 2 (carbon dioxide) level, while the kidneys regulate HCO 3-and H + (bicarbonate and hydrogen ions). [149] The kidneys play a key role in maintaining a constant level of acid-base balance in mammals. [30]

  7. Carbonic anhydrase - Wikipedia

    en.wikipedia.org/wiki/Carbonic_anhydrase

    The HCO 3-and H + are ideal for buffering pH in the blood and tissues because the pKa is close to the physiological pH = 7.2 – 7.6. Since HCO 3 - and H + are regulated in the kidneys and plasma carbon dioxide is regulated in the lungs, both actions in the kidneys and lungs are important to maintain the stability of blood pH.

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  9. Kidney - Wikipedia

    en.wikipedia.org/wiki/Kidney

    The kidney participates in the control of the ... range: Right kidney: ... concentration and decreases the pH. [citation needed] The kidneys have two cells that help ...