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Ex vivo lung perfusion, EVLP, is a form of machine perfusion aimed at sustaining the active aerobic cellular metabolism of donor lungs outside the donor's body prior to lung transplantation. This medical preservation technique typically occurs within a specialised machine engineered to mimic the conditions of the natural circulatory system .
Machine perfusion (MP) is an artificial perfusion technique often used for organ preservation to help facilitate organ transplantation.MP works by continuously pumping a specialized solution through donor organs, mimicking the body's natural blood flow while actively controlling temperature, oxygen levels, chemical composition, and mechanical stress within the organ.
Isolated organ perfusion technique is employed to precipitate an organ's perfusion and circulation that are independent/isolated from the body's systemic circulation for various purposes such as organ-localized chemotherapy, organ-targeted delivery of drug, gene or anything else, organ transplantation, and organ injury recovery.
A perfusionist in front of a heart–lung machine (upper right) early in a coronary artery bypass surgery. A cardiovascular perfusionist, clinical perfusionist or perfusiologist, and occasionally a cardiopulmonary bypass doctor [1] [2] or clinical perfusion scientist, [3] is a healthcare professional who operates the cardiopulmonary bypass machine (heart–lung machine) during cardiac surgery ...
United Therapeutics Corporation is an American publicly traded biotechnology company [2] and public benefit corporation [3] listed on the NASDAQ under the symbol UTHR. [4] [5] It develops novel, life-extending technologies for patients in the areas of lung disease and organ manufacturing.
These species often require large, cost-prohibitive doses of medications to treat systemically. Regional limb perfusion allows drug dose to be reduced while maintaining therapeutic concentrations at the site of interest, thereby reducing the cost of treatment, localizing application, decreasing systemic side effects, and improving efficacy. [2]
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Infusion therapy has a range of medical applications including sedation, anesthesia, post-operative analgesic pain management, chemotherapy, and treatment of infectious diseases Advantages of infusion therapy over other non-site-specific delivery methodologies are primarily efficacy through precision of medication delivery.