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Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, [4] Crohn's disease, and ulcerative colitis. [5]
Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating diarrhea symptoms and improving stool consistency and frequency. [4] Unlike other opiates, loperamide does not cross the blood brain barrier, so there is minimal risk for abuse. [5]
It contains loperamide and simethicone. Loperamide is a μ-opioid receptor agonist that works in the intestines. [1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal ...
Over-the-counter anti-diarrheal drugs, like Imodium, can offer short-term relief. But, don’t take it if you have a fever or bloody stools, and contact your doctor if you’re taking other ...
Federal health officials are investigating overdoses and deaths involving the use of anti-diarrhea drugs.
Diarrhea is defined by the World Health Organization as having three or more loose or liquid stools per day, or as having more stools than is normal for that person. [2] Acute diarrhea is defined as an abnormally frequent discharge of semisolid or fluid fecal matter from the bowel, lasting less than 14 days, by World Gastroenterology ...
Due to the risks associated with NSAIDs, people with existing kidney issues or a history of gastrointestinal bleeding should avoid taking them, says Mangan.
Opium tincture is indicated for the treatment of severe fulminant (intense, prolific) diarrhea that does not respond to standard therapy (e.g., Imodium or Lomotil). [31] The usual starting dose is 0.3 mL to 0.6 mL (about six to 12 drops) in a glass of water or juice four times a day. [ 31 ]
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