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2. Pituitary pars intermedia dysfunction - Wikipedia

   en.wikipedia.org/wiki/Pituitary_pars_intermedia...

   Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses. It is most commonly seen in older animals, [ 1 ] and is classically associated with the formation of a long, wavy coat ( hirsutism ) and chronic laminitis .

3. Cushing's disease - Wikipedia

   en.wikipedia.org/wiki/Cushing's_disease

   A basal central:peripheral ratio of over 2:1, or a ratio over 3:1 when CRH is administered, is indicative of Cushing's disease. [8] This test has been the gold standard for distinguishing between Cushing's disease and ectopic corticotropin syndrome, [ 8 ] with a sensitivity and specificity of 94% for Cushing's disease, [ 11 ] and a very low ...

4. Equine metabolic syndrome - Wikipedia

   en.wikipedia.org/wiki/Equine_metabolic_syndrome

   EMS shares similarities to pituitary pars intermedia dysfunction (also known as equine Cushing's disease), which also causes regional adiposity, laminitis, and sometimes insulin resistance. Treatment and management differ between the conditions, making it important to distinguish between the two.

5. Cushing's syndrome (veterinary) - Wikipedia

   en.wikipedia.org/wiki/Cushing's_syndrome...

   Treatment of Cushing's depends on the cause. It is possible to cure Cushing's if the tumour is small, benign, and located on the adrenal gland; however, this is not common. [2] [6] Hypophysectomy is an option for patients with good clinical signs and a high life expectancy. Inoperable pituitary tumours may be treated with radiation, this is ...

6. Horse management - Wikipedia

   en.wikipedia.org/wiki/Horse_management

   Others include a practice called gingering alleged to make a horse appear more energetic, but any behavioral changes are generally a result of discomfort caused by the treatment. Sometimes natural remedies are all that is available, particularly in the global south or other isolated remote areas.

7. Pergolide - Wikipedia

   en.wikipedia.org/wiki/Pergolide

   Pergolide is available for veterinary use. Under the trade name Prascend, manufactured by Boehringer Ingelheim, [7] it is commonly used for the treatment of pituitary hyperplasia at the pars intermedia or Equine Cushing's Syndrome (ECS) in horses. [6]

8. Trilostane - Wikipedia

   en.wikipedia.org/wiki/Trilostane

   Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...

9. Laminitis - Wikipedia

   en.wikipedia.org/wiki/Laminitis

   Pituitary pars intermedia dysfunction, or Cushing's disease, is common in older horses and ponies and causes an increased predisposition to laminitis. Equine metabolic syndrome is a subject of much new research and is increasingly believed to have a major role in laminitis. It involves many factors such as cortisol metabolism and insulin ...