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Hans Christian Ørsted (/ ˈ ɜːr s t ɛ d /; [5] Danish: [ˈhænˀs ˈkʰʁestjæn ˈɶɐ̯steð] ⓘ; often rendered Oersted in English; [note 1] 14 August 1777 – 9 March 1851) was a Danish physicist and chemist who discovered that electric currents create magnetic fields. This phenomenon is known as Oersted's law. He also discovered ...
In electromagnetism, Ørsted's law, also spelled Oersted's law, is the physical law stating that an electric current induces a magnetic field. [ 2 ] This was discovered on 21 April 1820 by Danish physicist Hans Christian Ørsted (1777–1851), [ 3 ] [ 4 ] when he noticed that the needle of a compass next to a wire carrying current turned so ...
Hershey–Chase experiment (by Alfred Hershey and Martha Chase) uses bacteriophage to prove that DNA is the hereditary material (1952). Meselson–Stahl experiment proves that DNA replication is semiconservative (1958). Crick, Brenner et al. experiment using frameshift mutations to support the triplet nature of the genetic code (1961).
Eukaryotes initiate DNA replication at multiple points in the chromosome, so replication forks meet and terminate at many points in the chromosome. Because eukaryotes have linear chromosomes, DNA replication is unable to reach the very end of the chromosomes. Due to this problem, DNA is lost in each replication cycle from the end of the chromosome.
Control of the DNA replication system ensures that the genome is replicated only once per cycle; over-replication induces DNA damage. Deregulation of DNA replication is a key factor in genomic instability during cancer development. [3] This highlights the specificity of DNA synthesis machinery in vivo. Various means exist to artificially ...
In 1820, Hans Christian Ørsted discovered that electric currents exerted forces on magnets, while in 1831, Michael Faraday made the observation that time-varying magnetic fields could induce electric currents. Until then, electricity and magnetism had been thought of as unrelated phenomena.
More than five decades ago, Jacob, Brenner, and Cuzin proposed the replicon hypothesis to explain the regulation of chromosomal DNA synthesis in E. coli. [18] The model postulates that a diffusible, trans-acting factor, a so-called initiator, interacts with a cis-acting DNA element, the replicator, to promote replication onset at a nearby origin.
Repeated applications of polymerase could lead to a chain reaction of replication for a specific segment of the genome – PCR. Later in 1983 Mullis began to test his idea. His first experiment [2] did not involve thermal cycling – he hoped that the polymerase could perform continued replication on its own. Later experiments that year ...