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MRI contrast agents may be administered by injection into the blood stream or orally, depending on the subject of interest. Oral administration is well suited to gastrointestinal tract scans, while intravascular administration proves more useful for most other scans. MRI contrast agents can be classified [2] by their: Chemical composition
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A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. [1] Contrast agents absorb or alter external electromagnetism or ultrasound , which is different from radiopharmaceuticals , which emit radiation themselves.
Enzyme-activated MR contrast agents are compounds that cause a detectable change in image intensity when in the presence of the active form of a certain enzyme. This makes them useful for in vivo assays of enzyme activity. They are distinguished from current, clinical MR contrast agents that give only anatomical information, [3] such as aqueous ...
Current research in molecular imaging involves cellular/molecular biology, chemistry, and medical physics, and is focused on: 1) developing imaging methods to detect previously undetectable types of molecules, 2) expanding the number and types of contrast agents available, and 3) developing functional contrast agents that provide information ...
[1] [2] Blood pool agents (also known as intravascular contrast agents) are differentiated from other contrast agents due to their high molecular weight and higher relaxivities. [3] Their large size prevents diffusion through the vascular epithelium and leakage into the interstitial space , and because of this they stay in the vascular system ...
The Molecular Imaging and Contrast Agent Database or MICAD is a freely accessible online source of information on in vivo molecular imaging agents. It was established as a key component of the "Molecular Libraries and Imaging" program of the NIH Roadmap, a set of major inter-agency initiatives accelerating medical research and the development of new, more specific therapies for a wide range of ...
However, most contrast agents used in MRI are selected for their specific magnetic properties. Most commonly, a paramagnetic contrast agent (usually a gadolinium compound [7] [8]) is given. Gadolinium-enhanced tissues and fluids appear extremely bright on T 1-weighted images. This provides high sensitivity for detection of vascular tissues (e.g ...