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Modafinil [13] Provigil Nevirapine [citation needed] Norfloxacin [14] Oseltamivir [citation needed] Oxicams [7] Ampiroxicam, Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam, Isoxicam: Paracetamol [15] [16] Acetaminophen, Panadol, Tylenol Penicillins [5] Phenytoin [5] Rivoraxaban [17] Xarelto: Sitagliptin [citation needed] Sulfonamides [2 ...
The drug has been found to block the dopamine transporter (DAT) by 83%, to a greater extent than methylphenidate without unfavorable concomitant adrenergic effects. [8] The drug is an atypical DRI similarly to modafinil. [11] [1] [9] The affinities for the DAT of flmodafinil's enantiomers and modafinil have also been studied.
The UK's National Institute for Health and Care Excellence (NICE), and the US's National Multiple Sclerosis Society, endorsed the off-label use of modafinil to alleviate fatigue associated with MS in 2022. [37] [38] MS-related fatigue is a common and often debilitating symptom experienced by people with multiple sclerosis.
Many patients will not develop these side effects, although there is still a significant possibility of risks associated with Antipsychotic usage. The percentage of patients affected by side effects like Tardive dyskinesia is significantly high and estimated to be a 20-50% prevalence. [1] [2]
The clinic also spent nearly $100,000 during that period on Provigil, a stimulant that is “55 times more expensive than the generic equivalent,” the report said.
Multiple sclerosis (MS) is an autoimmune disease resulting in damage to the insulating covers of nerve cells in the brain and spinal cord. [3] As a demyelinating disease , MS disrupts the nervous system's ability to transmit signals , resulting in a range of signs and symptoms , including physical, mental , and sometimes psychiatric problems.
Around 20% of MS patients with PML die, while most of the remaining are importantly disabled. [36] During clinical trials fingolimod gave rise to side effects such as hypertension and bradycardia, macular edema, elevated liver enzymes or reduction in lymphocyte levels. [39] [14] Teriflunomide is considered a very safe drug.
Provigil - used to treat excessive sleepiness and narcolepsy Prozac ( fluoxetine ) – an antidepressant of the SSRI class Luminal ( phenobarbital ) – a barbiturate with sedative and hypnotic properties
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