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Structural DNA nanotechnology, sometimes abbreviated as SDN, focuses on synthesizing and characterizing nucleic acid complexes and materials where the assembly has a static, equilibrium endpoint. The nucleic acid double helix has a robust, defined three-dimensional geometry that makes it possible to simulate, [ 26 ] predict and design the ...
Due to their structure and function, SNAs occupy a materials space distinct from DNA nanotechnology and DNA origami, [20] [21] (although both are important to the field of nucleic acid–guided programmable materials. [22] With DNA origami, such structures are synthesized via DNA hybridization events.
Nucleic acid design is central to the fields of DNA nanotechnology and DNA computing. [2] It is necessary because there are many possible sequences of nucleic acid strands that will fold into a given secondary structure, but many of these sequences will have undesired additional interactions which must be avoided.
DNA nanotechnology is the design and manufacture of artificial nucleic acid structures as engineering materials for nanotechnology rather than as the carriers of genetic information in living cells. The field uses branched DNA structures as fundamental components to create more complex, rationally designed structures.
The concepts of DNA nanotechnology later found further applications in DNA computing, [9] DNA nanorobotics, and self-assembly of nanoelectronics. [10] He shared the Kavli Prize in Nanoscience 2010 with Donald Eigler “for their development of unprecedented methods to control matter on the nanoscale.” [ 10 ] [ 11 ] He was a fellow of the ...
The method of DNA origami was developed by Paul Rothemund at the California Institute of Technology. [6] In contrast to common top-down fabrication methods such as 3D printing or lithography which involve depositing or removing material through a tool, DNA Nanotechnology, as well as DNA Origami as a subset, is a bottom-up fabrication method.
DNA quaternary structure varies over time, as regions of DNA are condensed or exposed for transcription. The term has also been used to describe the hierarchical assembly of artificial nucleic acid building blocks used in DNA nanotechnology. [3] The quaternary structure of DNA refers to the formation of chromatin.
The RNA tectonics methodology. Nadrian Seeman was the first one who proposed that DNA could be used as material for generating nanoscopic self-assembling structures. [2] This concept was extended to RNA by Jaeger and collaborators in 2000 by taking advantage of the concept of RNA tectonics initially proposed by Jaeger and Westhof and collaborators in 1996.
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