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DNA nanotechnology, specifically, is an example of bottom-up molecular self-assembly, in which molecular components spontaneously organize into stable structures; the particular form of these structures is induced by the physical and chemical properties of the components selected by the designers. [19]
Nano-scaffolding or nanoscaffolding is a medical process used to regrow tissue and bone, including limbs and organs. The nano-scaffold is a three-dimensional structure composed of polymer fibers very small that are scaled from a Nanometer (10 −9 m) scale. [ 1 ]
In 2006, Paul Rothemund made a breakthrough in DNA nanotechnology, developing the DNA origami. His DNA origami took a long, single-stranded DNA molecule (referred to as the "scaffold") and folded it into short, single-stranded DNA oligonucleotides (referred to as "staples").
The method of DNA origami was developed by Paul Rothemund at the California Institute of Technology. [6] In contrast to common top-down fabrication methods such as 3D printing or lithography which involve depositing or removing material through a tool, DNA Nanotechnology, as well as DNA Origami as a subset, is a bottom-up fabrication method.
This is an example of a scaffold. Scaffolding is a technique used in bioinformatics. It is defined as follows: [1] Link together a non-contiguous series of genomic sequences into a scaffold, consisting of sequences separated by gaps of known length. The sequences that are linked are typically contiguous sequences corresponding to read overlaps.
The concepts of DNA nanotechnology later found further applications in DNA computing, [9] DNA nanorobotics, and self-assembly of nanoelectronics. [10] He shared the Kavli Prize in Nanoscience 2010 with Donald Eigler “for their development of unprecedented methods to control matter on the nanoscale.” [ 10 ] [ 11 ] He was a fellow of the ...
Nucleic acid design is central to the fields of DNA nanotechnology and DNA computing. [2] It is necessary because there are many possible sequences of nucleic acid strands that will fold into a given secondary structure, but many of these sequences will have undesired additional interactions which must be avoided.
Due to their structure and function, SNAs occupy a materials space distinct from DNA nanotechnology and DNA origami, [20] [21] (although both are important to the field of nucleic acid–guided programmable materials. [22] With DNA origami, such structures are synthesized via DNA hybridization events.