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Doctors have termed this the “HAMA response,” referring to the development of Human Anti-Mouse Antibodies (HAMA). The HAMA response is essentially an allergic reaction to the mouse antibodies that can range from a mild form, like a rash, to a more extreme and life-threatening response, such as kidney failure. HAMA can also decrease the ...
Prepulse inhibition: preceding stimulus attenuates the startle response.. Prepulse inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong reflex-eliciting stimulus (pulse), often using the startle reflex.
Two-alternative forced choice (2AFC) is a method for measuring the sensitivity of a person or animal to some particular sensory input, stimulus, through that observer's pattern of choices and response times to two versions of the sensory input. For example, to determine a person's sensitivity to dim light, the observer would be presented with a ...
Spontaneous activity (or hypomotility) is determined by an open field test, in which a mouse is placed in a cage with perpendicular grid lines, usually spaced by approx. 1 inch. An experimenter counts the number of line crossings by the mouse in a given amount of time. Catalepsy is determined by the bar test. The mouse is placed on a bar ...
The tail suspension test (TST) is an experimental method used in scientific research to measure stress in rodents. It is based on the observation that if a mouse is subjected to short term inescapable stress then the mouse will become immobile.
The test can detect antipsychotic-like activity both in the case of dopamine D 2 receptor antagonists and in the case of drugs lacking D 2 receptor antagonism. [1] [2] [6] The occupancy of the D 2 receptor by antagonists of this receptor required to inhibit the CAR is around 65 to 80%, which is similar to the occupancy at which therapeutic antipsychotic effects occur in humans with these drugs.
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A Wistar rat, one of the animal species in which serotonergic psychedelics induce head twitches.. The head-twitch response (HTR), also sometimes known as wet dog shakes (WDS) in rats, is a rapid side-to-side head movement that occurs in mice and rats when the serotonin 5-HT 2A receptor is activated.