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Whereas uncommon side effects include: anaemia and elevated liver enzymes and rare side effects include: tachycardia and Fanconi syndrome. [24] Probenecid (a uricosuric drug) and intravenous saline should always be administered with each cidofovir infusion to prevent this nephrotoxicity.
Aciclovir, also known as acyclovir, [4] is an antiviral medication. [5] It is primarily used for the treatment of herpes simplex virus infections, chickenpox , and shingles . [ 6 ] Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein–Barr virus infection.
Nephrotoxicity — increase in serum creatinine levels and renal injury can occur in patients receiving foscarnet. [ 5 ] [ 16 ] Other nephrotoxic drugs should be avoided. Nephrotoxicity is usually reversible and can be reduced by dosage adjustment and adequate hydration.
The key is to try to keep down fluids to prevent dehydration, which can be a common side effect. Adults should drink water and most other fluids, including juice and sports drinks. Children can ...
How Hangovers Attack Your Mind and Body. When you drink too much, multiple organs feel the pain. The symptoms of a hangover can be wide-ranging and include dehydration, muscle pain, head-aches ...
Here's what causes food poisoning, when you should be worried and what can be done to prevent having to experience it in the first place. Food poisoning is extremely common. But that doesn't mean ...
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances , both toxic chemicals and medications , on kidney function . [ 1 ] There are various forms, [ 2 ] and some drugs may affect kidney function in more than one way.
Mutations occur in the enzymes that phosphorylate the drug and activate it: in the case of herpes simplex, resistance to acyclovir arises due to a mutation affecting the viral enzyme thymidine kinase. Since nucleoside analogues require two phosphorylations to be activated, one carried out by a viral enzyme and the other by enzymes in the host ...