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Blood irradiation therapy is an alternative medical procedure in which the blood is exposed to low-level light (often laser light) for therapeutic reasons. [1] The practice was originally developed in the United States, [ 1 ] but most recent research on it has been conducted in Germany (by UV lamps ) and in Russia (in all variants).
The irradiated patients experienced a wide variety of side-effects: nausea, vomiting, diarrhea, emaciation, hemorrhaging, fatigue, cognitive impairment, and hallucinations. [27] In the first month 21 patients died. [5] 1/4 of the patients died within 2 months of irradiation, and over 3/4 of the patients died within a year. [14]
Evaluation of the long-term outcomes in patients who were treated with TARGIT-IORT for breast cancer confirmed that it is as effective as whole breast external beam radiotherapy in controlling cancer, and also reduces deaths from other causes [16] as shown in a large international randomised clinical trial published in the British Medical Journal.
Radiation is a potential cause of cancer, and secondary malignancies are seen in some patients. Cancer survivors are already more likely than the general population to develop malignancies due to a number of factors including lifestyle choices, genetics, and previous radiation treatment.
Of 29 evaluated patients, there were 13 complete and 9 partial remissions, with an overall response rate of 76%. The most common adverse event was oral mucositis, oral pain, and fatigue. Based on the clinical results, it was concluded that BNCT was effective for the treatment of inoperable, previously irradiated patients with head and neck cancer.
Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation. As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung ...
Multiple studies have investigated this possibility, one being Jin. et al., 2020, where it was observed that circulating blood cells experienced a significantly lower impact during FLASH-RT, resulting in the killing of only 5-10% of cells, in contrast, CONV-RT exhibited a much more substantial effect, leading to the death of 90-100% of cells. [13]
Administration of prophylactic cranial irradiation increased 3-year survival from 15.3% to 20.7%. [10] [27] Standard radiation schedule of prophylactic cranial irradiation for limited stage small cell lung cancer patients is 25 Gy delivered at 2.5 Gy per fraction per day or 30 Gy delivered at 2 Gy per fraction per day. [1]