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2. Dimethyl fumarate - Wikipedia

   en.wikipedia.org/wiki/Dimethyl_fumarate

   Dimethyl fumarate (DMF) is the methyl ... Dimethyl fumarate is available as a generic ... invalid Biogen's so-called "514" patent protecting Tecfidera from generic ...

3. US Patent Office Grants Patent Claiming Dosing Regimen for ...

   www.aol.com/news/2013-03-19-us-patent-office...

   The article US Patent Office Grants Patent Claiming Dosing Regimen for TECFIDERA™ (Dimethyl Fumarate) originally appeared on Fool.com. Try any of our Foolish newsletter services free for 30 days .

4. Multiple sclerosis drug pipeline - Wikipedia

   en.wikipedia.org/wiki/Multiple_sclerosis_drug...

   Three generic immunomodulators: Glatiramer acetate (Copaxone, injection) Teriflunomide (Aubagio), [2] Monomethyl fumarate itself and its two precursors, which alters the NRF2 (nuclear factor erythroid 2(NF-E2)-related factor 2) transcription factor: Dimethyl fumarate (Tecfidera), [3] [4] Diroximel fumarate (Vumerity), [5] approved by the FDA in ...

5. Forward Pharma loses appeal in Tecfidera patent dispute with ...

   www.aol.com/news/forward-pharma-loses-appeal...

   A U.S. federal appeals court on Wednesday upheld a ruling that Biogen Inc's patents on its blockbuster multiple sclerosis drug Tecfidera are valid, rejecting a challenge by Danish drugmaker ...

6. CHMP Issues Positive Opinion for TECFIDERA™ (Dimethyl ... - AOL

   www.aol.com/news/2013-03-22-chmp-issues-positive...

   CHMP Issues Positive Opinion for TECFIDERA ™ (Dimethyl Fumarate) as a First-Line Treatment for Multiple Sclerosis in the European Union -European Commission Decision Anticipated In Second ...

7. NFE2L2 - Wikipedia

   en.wikipedia.org/wiki/NFE2L2

   Dimethyl fumarate, marketed as Tecfidera by Biogen Idec, was approved by the Food and Drug Administration in March 2013 following the conclusion of a Phase III clinical trial which demonstrated that the drug reduced relapse rates and increased time to progression of disability in people with multiple sclerosis. [6]

8. New TECFIDERA® (Dimethyl Fumarate) Data Show Sustained ... - AOL

   www.aol.com/news/2013-10-04-new-tecfidera...

   New TECFIDERA ® (Dimethyl Fumarate) Data Show Sustained Efficacy and Long-Term Safety in a Broad Range of Multiple Sclerosis Patients - Interim Results from ENDORSE Extension Study Reinforce ...

9. Fumaric acid - Wikipedia

   en.wikipedia.org/wiki/Fumaric_acid

   Fumarate is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food. It is formed by the oxidation of succinate by the enzyme succinate dehydrogenase. Fumarate is then converted by the enzyme fumarase to malate. Human skin naturally produces fumaric acid when exposed to ...