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Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. [1] The effect is most studied with grapefruit and grapefruit juice, [1] but similar effects have been observed with certain other citrus fruits.
The pomelo, while not itself toxic, can cause adverse interactions similar to those caused by the grapefruit with a wide range of prescription drugs. These occur by the inhibition of cytochrome P450 -mediated metabolism of prescription drugs including for example some anti-hypertensives , some anticoagulants , some anticancer agents , some anti ...
In the past it was called the pomelo, [3] but that term is now mostly used as the common name for Citrus maxima. [4] Grapefruit–drug interactions are common, as the juice contains furanocoumarins that interfere with the metabolism of many drugs. This can prolong and intensify the effects of those drugs, leading to multiple side-effects such ...
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds:
The toxin can sometimes be found even in the most common foods, including carrots, parsley, limes, and lemons, as reported in the New England Journal of Medicine in the case of a man who manually squeezed a dozen limes and then inadvertently exposed his hand directly to the sunlight without precaution, triggering a severe phytophotodermatitis ...
“Ultimately, we're prescribing these medications to improve people’s lives,” Dr. Russo says. “If they're not doing that, we need to do something to change it.” You Might Also Like
Bergamottin, dihydroxybergamottin, or synthetic analogs may be developed as drugs that are targeted to increase the oral bioavailability of other drugs. Drugs that may have limited use because they are metabolized by CYP3A4 may become viable medications when taken with a CYP3A4 inhibitor because the dose required to achieve a necessary ...
Image credits: Gilbert Flores/Variety/Getty Images Celebrity use and social media promotion of Ozempic have reportedly contributed to a shortage of the drug, which is intended to treat diabetes.