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Oncotic pressure, or colloid osmotic-pressure, is a type of osmotic pressure induced by the plasma proteins, notably albumin, [1] in a blood vessel's plasma (or any other body fluid such as blood and lymph) that causes a pull on fluid back into the capillary.
The Starling principle holds that extracellular fluid movements between blood and tissues are determined by differences in hydrostatic pressure and colloid osmotic pressure (oncotic pressure) between plasma inside microvessels and interstitial fluid outside them.
In medicine, hydrostatic pressure in blood vessels is the pressure of the blood against the wall. It is the opposing force to oncotic pressure. In capillaries, hydrostatic pressure (also known as capillary blood pressure) is higher than the opposing “colloid osmotic pressure” in blood—a “constant” pressure primarily produced by ...
Mean blood pressure drops over the whole circulation, although most of the fall occurs along the small arteries and arterioles. [35] Gravity affects blood pressure via hydrostatic forces (e.g., during standing), and valves in veins, breathing, and pumping from contraction of skeletal muscles also influence blood pressure in veins. [32]
For example, when blood pressure drops in circulatory shock, Starling forces drive fluid into the interstitium, causing third spacing. [11] Standing still for a prolonged period will cause an increase in transcapillary hydrostatic pressure. As a result, approximately 12% of blood plasma volume will cross into the extravascular compartment.
Increase hydrostatic pressure in vessels: left ventricular heart failure, Decrease oncotic pressure in blood vessels: Cirrhosis (Cirrhosis leads to hypoalbuminemia and decreasing of colloid oncotic pressure in plasma that causes edema) Nephrotic syndrome (also due to hypoalbuminemia caused by proteinuria). Malnutrition (hypoalbuminism)
Hydrostatic pressure within blood vessels tends to cause water to filter out into the tissue. This leads to a difference in protein concentration between blood plasma and tissue. As a result, the colloidal or oncotic pressure of the higher level of protein in the plasma tends to draw water back into the blood vessels from the tissue. Starling's ...
The arterial blood plasma, interstitial fluid and lymph interact at the level of the blood capillaries. The capillaries are permeable and water can move freely in and out. At the arteriolar end of the capillary the blood pressure is greater than the hydrostatic pressure in the tissues.