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2157 14069 Ensembl ENSG00000185010 ENSMUSG00000031196 UniProt P00451 Q06194 RefSeq (mRNA) NM_000132 NM_019863 NM_001161373 NM_001161374 NM_007977 RefSeq (protein) NP_000123 NP_063916 NP_001154845 NP_001154846 NP_032003 Location (UCSC) Chr X: 154.84 – 155.03 Mb Chr X: 74.22 – 74.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coagulation factor VIII (Factor VIII, FVIII, also ...
The best known and most common hereditary form is Factor V Leiden, which is responsible for more than 95% of cases. [5] Other genetic causes include Factor V Cambridge (VThr306) and the factor V HR2 haplotype (A4070G mutation). [5] [6] Acquired forms of APC resistance occur in the presence of elevated Factor VIII concentrations.
VIII 460–519: Diseases of the Respiratory System IX 520–579: Diseases of the Digestive System X 580–629: Diseases of the Genitourinary System XI 630–679: Complications of Pregnancy, Childbirth, and the Puerperium XII 680–709: Diseases of the Skin and Subcutaneous Tissue XIII 710–739: Diseases of the Musculoskeletal System and ...
Polycythemia is defined as serum hematocrit (Hct) or hemoglobin (HgB) exceeding normal ranges expected for age and sex, typically Hct >49% in healthy adult men and >48% in women, or HgB >16.5 g/dL in men or >16.0 g/dL in women. [8] The definition is different for neonates and varies by age in children. [9] [10]
Elevated homocysteine is a known risk factor for cardiovascular disease as well as thrombosis. [7] It has also been shown to be associated with microalbuminuria which is a strong indicator of the risk of future cardiovascular disease and renal dysfunction. [8]
Human Chr 3. In terms of the cause of protein S deficiency it can be in inherited via autosomal dominance.A mutation in the PROS1 gene triggers the condition. The cytogenetic location of the gene in question is chromosome 3, specifically 3q11.1 [6] [7] Protein S deficiency can also be acquired due to vitamin K deficiency, treatment with warfarin, liver disease, kidney disease, chemotherapy ...
[10] Once the reactive causes of thrombocythemia are ruled out, clonal thrombocythemia should be considered. The most common cause of clonal thrombocythemia is a myeloproliferative neoplasm. These include: essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and primary myelofibrosis. [8]
[9] [10] Immunohistochemistry demonstrates that vascular endothelial cells are positive for Factor VIII, vimentin, CD31, and CD34 antibodies, [11] [12] but negative for Bcl-2 and HHV-8 antigens. [13] [14] Vimentin, Factor XIIIa, CD68, alpha-1-antitrypsin, and lysozyme are expressed by mononuclear cells, [11] [13] although neither S100 nor CD1a ...