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The hormone gastrin and the vagus nerve trigger the release of both pepsinogen and HCl from the stomach lining when food is ingested. Hydrochloric acid creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, thereby generating pepsin (the active form). Pepsin cleaves the 44 amino acids ...
n/a Ensembl ENSG00000229859 n/a UniProt P0DJD8 n/a RefSeq (mRNA) NM_001079807 n/a RefSeq (protein) NP_001073275 n/a Location (UCSC) Chr 11: 61.2 – 61.21 Mb n/a PubMed search n/a Wikidata View/Edit Human Pepsinogen 3, group I (pepsinogen A) is a protein that in humans is encoded by the PGA3 gene. Function This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the ...
Chief cells are part of fundic gland polyps (here shown in high magnification). [11]In gastric tissue, a loss of parietal cells due to chronic inflammation has been shown to affect chief cell differentiation and can induce chief cells to transdifferentiate back into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing metaplasia (SPEM ...
A gastric chief cell, peptic cell, or gastric zymogenic cell is a type of gastric gland cell that releases pepsinogen and gastric lipase.It is the cell responsible for secretion of chymosin (rennin) in ruminant animals and some other animals. [1]
The following are enzymes produced by the stomach and their respective function: Pepsin is the main gastric enzyme. It is produced in the stomach by gastric chief cells in its inactive form pepsinogen, which is a zymogen. Pepsinogen is then activated by the stomach acid into its active form, pepsin.
Gastric chief cells produce pepsinogen, which is activated by the acid to form pepsin. Pepsin is a protease that can digest and damage stomach cells. To prevent these disastrous effects, mucus and bicarbonate ions (HCO 3 −) are secreted by the foveolar cells.
The oxyntic gland contains the parietal cells that produce hydrochloric acid and intrinsic factor, and chief cells that produce pepsinogen and gastric lipase. The pyloric gland is found in the pyloric region, the remaining 20 per cent of the stomach. The pyloric glands are mainly in the pyloric antrum. The pyloric gland secretes gastrin from ...
1 Function. 2 Clinical significance. 3 See ... Progastricsin also known as pepsinogen C or pepsinogen II is a pepsinogen precursor of the enzyme gastricsin that in ...