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Hyperpigmentation is believed to be related to the enzyme tyrosinase which produces melanin. Among several chemicals known to inhibit tyrosinase production, such as hydroquinone , arbutin , and kojic acid , 4-butylresorcinol has been found to be the most powerful inhibitor by a wide margin.
Azelaic acid is used for treatment of skin pigmentation, including melasma and postinflammatory hyperpigmentation, particularly in those with darker skin types. It has been recommended as an alternative to hydroquinone. [25] As a tyrosinase inhibitor, [5] azelaic acid reduces synthesis of melanin. [26]
This toner takes skin-brightening to the next level by pairing kojic acid with vitamin C — yet another tyrosinase inhibitor — as well as bearberry extract, a plant-based alternative to ...
Thyroid hormones, another early weight loss drug, also raised energy expenditure but ceased to be used for weight loss due to cardiac risks and other adverse effects. [18] Selective thyromimetics that work on the thyroid hormone receptor beta may be able to exert some of the beneficial thermogenic effects of thyroid hormones with fewer adverse ...
Eli Lilly’s weight loss drug Zepbound is no longer in short supply, the FDA said, worrying patients who use cheaper, off-brand versions of the drug. On Thursday, Dec. 19, the U.S. Food and Drug ...
The weight loss drug Zepbound, generically known as tirzepatide, is also now an approved medication to treat obstructive sleep apnea, per a Food and Drug Administration Dec. 20 press release.
Orlistat is used for the treatment of obesity.The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat.
There are positives to this effect—namely weight loss, but also potentially treating substance use and addiction, likely due to GLP-1s’ effect on the hypothalamus.
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