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Nowadays, the MIC is used in antimicrobial susceptibility testing. The MIC is reported by providing the susceptibility interpretation next to each antibiotic. The different susceptibility interpretations are: "S" (susceptible or responding to a standard dosing regimen), "I" (intermediate or requiring increased exposure), and "R" (resistant).
Bacteria are marked as sensitive, resistant, or having intermediate resistance to an antibiotic based on the minimum inhibitory concentration (MIC), which is the lowest concentration of the antibiotic that stops the growth of bacteria. The MIC is compared to standard threshold values (called "breakpoints") for a given bacterium and antibiotic. [28]
Interpretation is more complicated in mixed susceptibility populations. These are plotted as linear dimensions or squares of distances as a function of the natural logarithm of antibiotic concentration in the disks. The MIC is determined from the zero intercept of a linear regression fit through the data. [12]
The above eight rules apply to a chart of a variable value. A second chart, the moving range chart, can also be used but only with rules 1, 2, 3 and 4. Such a chart plots a graph of the maximum value - minimum value of N adjacent points against the time sample of the range.
The "chart" actually consists of a pair of charts: one, the individuals chart, displays the individual measured values; the other, the moving range chart, displays the difference from one point to the next.
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As with the ¯ and R and individuals control charts, the ¯ chart is only valid if the within-sample variability is constant. [5] Thus, the s chart is examined before the x ¯ {\displaystyle {\bar {x}}} chart; if the s chart indicates the sample variability is in statistical control, then the x ¯ {\displaystyle {\bar {x}}} chart is examined to ...