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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development , cell growth, morphogenesis , tissue repair, tumor growth and invasion.
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone .
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of ...
A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 [14] and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast ...
PLCγ1 is a cell growth factor [7] [8] from the PLC superfamily. PLCγ1 is used during cell growth [7] and in cell migration [9] and apoptosis, [8] all of which are vital cell processes that, if disrupted by mutations, can cause cancerous cells to form within the body.
21809 Ensembl ENSG00000119699 ENSMUSG00000021253 UniProt P10600 P17125 RefSeq (mRNA) NM_003239 NM_001329938 NM_001329939 NM_009368 RefSeq (protein) NP_001316867 NP_001316868 NP_003230 n/a Location (UCSC) Chr 14: 75.96 – 75.98 Mb Chr 12: 86.1 – 86.13 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor beta-3 is a protein that in humans is encoded by the ...
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Linear growth is a complex process regulated by the growth hormone (GH) – insulin-like growth factor-1 axis, the thyroxine/triiodothyronine axis, androgens, estrogens, vitamin D, glucocorticoids and possibly leptin. [25] GH is secreted by the anterior pituitary gland in response to hypothalamic, pituitary and circulating factors.