Search results
Results from the WOW.Com Content Network
PLCγ1 is a cell growth factor [7] [8] from the PLC superfamily. PLCγ1 is used during cell growth [7] and in cell migration [9] and apoptosis, [8] all of which are vital cell processes that, if disrupted by mutations, can cause cancerous cells to form within the body.
FLT1 is a member of VEGF receptor gene family. It encodes a receptor tyrosine kinase which is activated by VEGF-A, VEGF-B, and placental growth factor.The sequence structure of the FLT1 gene resembles that of the FMS (now CSF1R) gene; hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.
VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). [1] [2] There are three main subtypes of VEGFR, numbered 1, 2 and 3.Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).
Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. [7] Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development , cell growth, morphogenesis , tissue repair, tumor growth and invasion.
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor . It was also named Krox-24, TIS8, and ZENK .
Gfi1 (growth factor independence 1) is a transcriptional repressor that plays a critical role in hematopoiesis and in protecting hematopoietic cells against stress-induced apoptosis. Recent research has shown that Gfi1 upregulates the expression of the nuclear protein Hemgn , which contributes to its anti-apoptotic activity.