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Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [8] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [8] It is used either by mouth or injection into a muscle. [8] Hydroxyzine works by blocking the effects of histamine. [9]
“It is mostly older antihistamines, such as Benadryl and hydroxyzine, where drug interactions occur.” ... after trying both, believe that one performs better than the other or, conversely, one ...
Diphenhydramine: 50 mg 2–3 hours 2–9 hours CYP2D6, others Yes Doxylamine: 25 mg 2–3 hours 10–12 hours CYP2D6, others Yes Hydroxyzine: 25–100 mg 2 hours 20 hours ADH, CYP3A4, others No Doxepin: 3–6 mg 2–3 hours 17 hours c: CYP2D6, others No (at low doses) Mirtazapine: 7.5–15 mg 2 hours 20–40 hours CYP2D6, others No Quetiapine e ...
The most common antihistamines utilized for this purpose include hydroxyzine, promethazine (enzyme induction especially helps with codeine and similar prodrug opioids), phenyltoloxamine, orphenadrine, and tripelennamine; some may also have intrinsic analgesic properties of their own, orphenadrine being an example.
Diphenhydramine, available in various salt forms, [73] such as citrate, [74] [75] hydrochloride, [76] and salicylate, [77] exhibits distinct molecular weights and pharmacokinetic properties. Specifically, diphenhydramine hydrochloride and diphenhydramine citrate possess molecular weights of 291.8 g/mol [ 78 ] and 447.5 g/mol , [ 79 ] respectively.
A 10 mg dose of cetirizine equals about a 30 mg dose of hydroxyzine in terms of peripheral antihistamine effect.) [31] PET studies with antihistamines have found that brain H 1 receptor occupancy of more than 50% is associated with a high prevalence of somnolence and cognitive decline, whereas brain H 1 receptor occupancy of less than 20% is ...
Clemastine is an antihistamine with anticholinergic and sedative effects. Antihistamines competitively bind to histamine receptor sites, thus reducing the neurotransmitter's effects. [9]
Vistaril (hydroxyzine) – an antihistamine for the treatment of itches and irritations, an antiemetic, as a weak analgesic, an opioid potentiator, and as an anxiolytic; Vyvanse (lisdexamfetamine) – a pro-drug stimulant used to treat attention deficit hyperactivity disorder and binge eating disorder; Vyvanse is converted into Dexedrine in vivo
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