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Immediate-release melatonin has a short elimination half-life of about 20 to 50 minutes. [22] [9] [10] Prolonged-release melatonin used as a medication has a half-life of 3.5 to 4 hours. [11] [8] Melatonin was discovered in 1958. [9]
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
The Life Extension Foundation (LEF) was primarily funded by the sale of nutritional supplements to members of an affiliated entity, the Life Extension Buyer's Club. [citation needed] The Life Extension Buyer's Club was incorporated in Nevada, and has a separate EIN employer number than the Life Extension Foundation. Its name was changed to the ...
Is melatonin or ashwagandha safer for sleep? Since sleep medications can cause significant problems, Teitelbaum likes to start with natural, safer alternatives like melatonin and ashwagandha.
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. [1]
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