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Hormone secreting pituitary adenomas cause one of several forms of hyperpituitarism.The specifics depend on the type of hormone. Some tumors secrete more than one hormone, the most common combination [8] being GH and prolactin, which present as Gigantism or Acromegaly and unexpected lactation (in both men and women).
Hyperparathyroidism is present in ≥ 90% of patients. Asymptomatic hypercalcemia is the most common manifestation: about 25% of patients have evidence of nephrolithiasis or nephrocalcinosis. In contrast to sporadic cases of hyperparathyroidism, diffuse hyperplasia or multiple adenomas are more common than solitary adenomas.
The usual suspects are pituitary adenomas, craniopharyngiomas, and meningiomas. Pituitary tumors are the most common cause of chiasmal syndromes. Visual field defects may be one of the first signs of non-functional pituitary tumor. These are much less frequent than functional adenomas.
This is an accepted version of this page This is the latest accepted revision, reviewed on 15 January 2025. Neoplasm in the brain Medical condition Brain tumor Other names Intracranial neoplasm, brain tumour, brain cancer Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging Specialty Neurosurgery, neuro-oncology Symptoms Vary depending on the ...
Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, [3] when excluding Cushing's syndrome from exogenously administered corticosteroids. The equine version of this disease is Pituitary pars intermedia dysfunction. This should not be confused with ectopic Cushing syndrome or exogenous steroid use. [4]
A physician's response to detecting an adenoma in a patient will vary according to the type and location of the adenoma among other factors. [citation needed] Different adenomas will grow at different rates, but typically physicians can anticipate the rates of growth because some types of common adenomas progress similarly in most patients.
The most common cause of hyperprolactinemia is prolactinoma (a type of pituitary adenoma). [3] A blood serum prolactin level of 1000–5000 mIU/L (47–235 ng/mL) may arise from either mechanism, however levels >5000 mIU/L (>235 ng/mL) is likely due to the activity of an adenoma .
Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones; [3] [medical citation needed] it typically results from a pituitary adenoma.In children with hyperpituitarism, disruption of growth regulation is rare, either because of hormone hypersecretion or because of manifestations caused by local compression of the adenoma.
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