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Components that are essential for osteoblast bone formation include mesenchymal stem cells (osteoblast precursor) and blood vessels that supply oxygen and nutrients for bone formation. Bone is a highly vascular tissue, and active formation of blood vessel cells, also from mesenchymal stem cells, is essential to support the metabolic activity of ...
The osteoblast then deposits calcium phosphate which is hardened by hydroxide and bicarbonate ions. The brand-new bone created by the osteoblast is called osteoid. [24] Once the osteoblast is finished working it is actually trapped inside the bone once it hardens. When the osteoblast becomes trapped, it becomes known as an osteocyte.
Diagram showing stages of endochondral ossification. Endochondral ossification is the formation of long bones and other bones. This requires a hyaline cartilage precursor. There are two centers of ossification for endochondral ossification. The primary center. In long bones, bone tissue first appears in the diaphysis (middle of shaft).
After the bone is completely ossified, the osteoblasts retract their calcium phosphate secreting tendrils, leaving tiny canals in the bony matrix, known as canaliculi. These canaliculi provide the nutrients needed for the newly transformed osteoblasts, which are now called osteocytes. These cells are responsible for the general maintenance of ...
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Eventually, all of the cells within the nidus develop into, and display the morphologic characteristics of, an osteoblast. Then the osteoblasts create an extracellular matrix containing Type-I collagen fibrils, which is osteoid. The osteoblasts, while lining the periphery of the nidus, continue to form osteoid in the center of the nidus.
Section of fetal bone of cat. ir. Irruption of the subperiosteal tissue. p. Fibrous layer of the periosteum. o. Layer of osteoblasts. im. Subperiosteal bony deposit. There are two types of ossification centers – primary and secondary. A primary ossification center is the first area of a bone to start ossifying.
Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. [6] Osteocyte activity plays a key role in this process. Conditions that result in a decrease in bone mass can either be caused by an increase in resorption or by a decrease in ossification. During childhood, bone formation exceeds resorption.