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Selenium is toxic in high concentrations. As sodium selenite, the chronic toxic dose for human beings was described as about 2.4 to 3 milligrams of selenium per day. [7] In 2000, the US Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 μg/day. [8]
Selenomethionine (SeMet) is a naturally occurring amino acid.The L-selenomethionine enantiomer is the main form of selenium found in Brazil nuts, cereal grains, soybeans, and grassland legumes, while Se-methylselenocysteine, or its γ-glutamyl derivative, is the major form of selenium found in Astragalus, Allium, and Brassica species. [1]
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An individual will most likely be prescribed selenium supplements (in the form of selenomethionine) or have injections of this mineral. Other recommendations for managing Keshan disease are to increase consumption of foods rich in selenium in addition to supplements, avoid alcohol, monitor side effects to medications, and increase sleep.
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As such, it is extremely toxic and must be handled with care. For a 70 kilograms (150 lb) person, this dosage corresponds to 112 mg, or, in terms of 200 μg pills, 560 pills. Chronic exposure to sodium selenate can cause severe lung, kidney, and liver damage. [9] Overexposure to selenium in the diet leads to a condition known as selenosis.
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