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Lidocaine is a common class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. [10]
However, care should be taken as the high doses of viscous lidocaine my cause adverse effects. [12] A study reported that lidocaine has a potential toxicity; when it was tested on patients with oral mucositis who underwent a bone marrow transplant, lidocaine anesthetic mouthwash was found to be systemically absorbed. [13]
This is because lidocaine selectively blocks Na channels in their open and inactive states and has little binding capability in the resting state. Class Ib agents are indicated for the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.
Hillary Brown was taken to a hospital “in cardiac arrest with an elevated lactic acid level and suspected lidocaine toxicity,” health officials noted. ... Dr. Brown’s treatment of (his wife ...
Other treatment that may be used to treat life-threatening arrhythmias until Fab is acquired are magnesium, phenytoin, and lidocaine. Magnesium suppresses digoxin-induced ventricular arrhythmias while phenytoin and lidocaine suppresses digoxin-induced ventricular automaticity and delay afterdepolarizations without depressing AV conduction.
Hillary Brown was taken to a trauma center by emergency responders "with an elevated lactic acid level and suspected lidocaine toxicity." She never regained consciousness and died on Nov. 28, 2023.
Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
A 2024 study published in Anesthesiology showed that lidocaine cream could help with neck pain, particularly muscle-related pain. According to researchers, this is because the cream easily reaches ...
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