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The Centre for Regenerative Medicine (CRM) is a stem cell research centre at the University of Edinburgh in Scotland, dedicated to the study and development of new regenerative treatments for human diseases. [2] The centre forms part of the university's Institute for Regeneration and Repair and is part of the BioQuarter cluster at Little France ...
Astellas Institute for Regenerative Medicine is a subsidiary of Astellas Pharma located in Marlborough, Massachusetts, US, developing stem cell therapies with a focus on diseases that cause blindness. It was formed in 1994 as a company named Advanced Cell Technology, Incorporated (ACT), which was renamed to Ocata Therapeutics in November 2014. [3]
NYSCF was founded in New York City by Susan L. Solomon, a lawyer and entrepreneur, and Mary Elizabeth Bunzel, a former journalist, in 2005 to accelerate stem cell-based approaches to researching and treating type 1 diabetes [3] and in response to the refusal of the administration of President George W. Bush to make a major investment in stem cell research. [1]
[31] [32] This accounting has become an educational feature of cell biology texts. Marth and other colleagues have called attention to the fact that only half of these macromolecules are encoded by the genome, suggesting that a more holistic approach is needed in biomedical research to fully understand and intervene in the origins and ...
Foxp3 is a specific marker of natural T regulatory cells (nTregs, a lineage of T cells) and adaptive/induced T regulatory cells (a/iTregs), also identified by other less specific markers such as CD25 or CD45RB. [6] [7] [8] In animal studies, Tregs that express Foxp3 are critical in the transfer of immune tolerance, especially self-tolerance. [13]
The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. [5] It is a 13kbp gene on chromosome 21q22.3 that encodes 545 amino acids. [6] AIRE is a transcription factor expressed in the medulla [broken anchor] (inner part) of the thymus.
In 1998, Thomson's Lab was the first to report the successful isolation of human embryonic stem cells. On November 6, 1998, Science published this research in an article titled "Embryonic Stem Cell Lines Derived from Human Blastocysts", results which Science later featured in its “Scientific Breakthrough of the Year” article, 1999. [3]
[2] [3] [4] He is a professor and the director emeritus of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application, Kyoto University; [6] as a senior investigator at the UCSF-affiliated Gladstone Institutes in San Francisco, California; and as a professor of anatomy at University of California, San Francisco (UCSF).