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The average concordance rates are higher for identical twins than for ... and Surinam, to discover that rates of schizophrenia from those living in the Netherlands ...
A twin study compares the concordance rate of identical twins to that of fraternal twins. This can help suggest whether a disease or a certain trait has a genetic cause. [3] Controversial uses of twin data have looked at concordance rates for homosexuality and intelligence. Other studies have involved looking at the genetic and environmental ...
[6] [7] That said, the fact that even monozygotic twins don't share a 100% concordance rate suggests environmental factors play a role in the vulnerability and development of the disorder. Maternal immune responses are involved in schizophrenia development.
The question of how schizophrenia could be primarily genetically influenced, given that people with schizophrenia have lower fertility rates, is a paradox. It is expected that genetic variants that increase the risk of schizophrenia would be selected against, due to their negative effects on reproductive fitness .
Twin studies that investigated the development of schizophrenia found that identical twins have a higher concordance rate for schizophrenia than non-identical twins. [18] [19] [20] However, none of them found a 100% concordance rate from identical twins. Identical twins have exact genes.
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