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Low energy levels and stress: The AMP-dependent protein kinase AMPK phosphorylates and thereby activates TSC1-TSC2 by phosphorylating at least 2 residues of TSC2. [7] Hypoxia: The Hypoxia-inducible factor α HIFα induces REDD1 at low oxygen levels. REDD1 has been shown to activate TSC1-TSC2 by neutralisation of AKT dependent inhibition. [8]
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The 21st TSC originated as a maintenance support headquarters under Seventh Army Support Command, the brigade's first home was Taylor Barracks, Mannheim, Germany. After the United States military withdrawal from France in 1967 and the organization of the U.S. Theater Army Support Command, Europe, informally known as TASCOM, the brigade became ...