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The hallmarks of cancer were originally six biological capabilities acquired during the multistep development of human tumors and have since been increased to eight capabilities and two enabling capabilities. The idea was coined by Douglas Hanahan and Robert Weinberg in their paper "The Hallmarks of Cancer" published January 2000 in Cell. [1]
It covers research on all aspects of cancer and cancer-related biomedical sciences and was established in 1941. The editor-in-chief is Chi Van Dang. [1] The journal was established in 1916 as the Journal of Cancer Research, was renamed American Journal of Cancer in 1931, and obtained its current name in 1941.
Sidney Farber is regarded as the father of modern chemotherapy.. Cancer research has been ongoing for centuries. Early research focused on the causes of cancer. [1] Percivall Pott identified the first environmental trigger (chimney soot) for cancer in 1775 and cigarette smoking was identified as a cause of lung cancer in 1950.
Cancer Discovery has become a premier journal in the field of cancer research, with a 2020 impact factor of 39.397 that is the highest among the AACR journals. [6] [7] Research published in the journal includes identification of actionable genomic alterations in cancer, mechanisms of therapy resistance, clinical trials on targeted therapy, and ...
The first issue of Clinical Cancer Research was published in January 1995. [2] By 1 December 1994, 128 manuscripts had been submitted for publication by investigators representing a variety of clinical and laboratory disciplines not only from the United States but also from the international research community. In 1998, the number of ...
In their landmark paper, The Hallmarks of Cancer, [3] Hanahan and Weinberg suggest that cancer can be described by a small number of underlying principles, despite the complexities of the disease. The authors describe how tumor progression proceeds via a process analogous to Darwinian evolution, where each genetic change confers a growth ...
The concept of the tumor microenvironment (TME) dates back to 1863 when Rudolf Virchow established a connection between inflammation and cancer. However, it was not until 1889 that Stephen Paget's seed and soil theory introduced the important role of TME in cancer metastasis, highlighting the intricate relationship between tumors and their surrounding microenvironment.
Cancer Discovery is a monthly peer-reviewed medical journal published by the American Association for Cancer Research. It covers research and clinical trials related to the study of cancer. The editors-in-chief are Lewis C. Cantley and Luis A. Diaz. [1] The journal was established in 2011. [1]
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