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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-018, JWH-073, CP 47,497 (and its homologues), and HU-210, as well as leonotis leonurus, have been all banned in Latvia since 2005. [128] After the first confirmed lethal case from the use of legal drugs in late 2013, parliament significantly increased the number of temporarily banned substances used in Spice and similar preparations.
FUB-JWH-018 (also known as FUB-018) is a naphthoylindole-based synthetic cannabinoid, representing a molecular hybrid of JWH-018 and AB-FUBICA or ADB-FUBICA. [ 1 ] [ 2 ] Legal status
JWH-018 was banned by controlled substances act on December 21, 2012. Law enforcement officials in Canada asked Huffman to serve as a consultant and expert witness. He received numerous media queries and requests for analytical help from law enforcement officials.
JWH-007 [5] Naphthoylindole: 9.5 ± 4.5: 2.9 ± 2.6: CB 2 (3.3x) JWH-009: Naphthoylindole >10000: 141 ± 14: CB 2 (>70x) JWH-011: Naphthoylindole: JWH-015 [5] Naphthoylindole: 164 ± 22: 13.8 ± 4.6: CB 2 (12x) JWH-016: Naphthoylindole: 22 ± 1.5: 4.3 ± 1.6: CB 2 (5.1x) JWH-018 [5] Naphthoylindole: 9 ± 5: 2.9 ± 2.6: CB 2 (3.1x) JWH-019 ...
UGT1A1, UGT1A3, UGT1A9, UGT1A10 and UGT2B7 isoenzymes were primarily responsible for JWH-018 and JWH-073 metabolites’ conjugation and had high affinity for hydroxylated metabolites (Km=12–18 mmol/L). Generation of JWH-018-N-4- and 5-hydroxypentyl (JWH-018 metabolites) was primarily mediated by CYP2C9 followed by CYP1A2 and CYP2C19. CYP3A4 ...
THJ-018; Legal status; Legal status: CA: ... is a synthetic cannabinoid that is the indazole analogue of JWH-018 and has been sold online as a designer drug. [1] [2]
Section in question: "In most other countries JWH-018 remains legal at present, although it might potentially be deemed a controlled substance analogue in certain jurisdictions where very broadly worded drug analogues laws are in force. JWH-018 is unlike any known illegal cannabinoid, and thus is not subject to various analogue acts."