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Anonychia is the failure to form fingernails or toenails. [ 1 ] It is an anomaly which may be the result of a congenital ectodermal defect, ichthyosis , severe infection, severe allergic contact dermatitis , self-inflicted trauma , Raynaud phenomenon , lichen planus , epidermolysis bullosa , or severe exfoliative diseases.
Nail abnormalities in ED often manifest as dysplastic or poorly formed nails. Affected individuals may have thin, brittle, or ridged nails that are prone to splitting and breaking. In severe cases, nails may be entirely absent or exhibit atypical growth patterns, including spoon-like (koilonychia) or thickened (pachyonychia) appearances. [1] [2]
Onychomadesis is a periodic idiopathic shedding of the nails beginning at the proximal end, possibly caused by the temporary arrest of the function of the nail matrix. [1]: 784 [2]: 660 One cause in children is hand, foot, and mouth disease. [3] This generally resolves without complication.
Nail clubbing - nails that curve down around the fingertips with nailbeds that bulge is associated with oxygen deprivation and lung, heart, or liver disease. Koilonychia - spooning, or nails that grow upwards. Associated with iron-deficiency anaemia or vitamin B 12 deficiency. [citation needed] Pitting of the nails is associated with psoriasis.
The hair is often light-coloured, brittle, and slow-growing. This condition is also characterized by absent teeth or teeth that are malformed. Hypohidrotic ectodermal dysplasia is the most common form of ectodermal dysplasia in humans. It is estimated to affect at least 1 in 17,000 people worldwide. [citation needed]
When the condition occurs on all the twenty nails of the fingers and toes, it is known as twenty-nail dystrophy, most evident in childhood, [4] favoring males. [ 2 ] [ 5 ] Trachyonychia causes the nails to become opalescent, thin, dull, fragile, and finely longitudinally ridged, and, as a result, distally notched. [ 6 ]
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Severe congenital onychogryphosis affecting all twenty nailbeds has been recorded in two families who exhibit the dominant allele for a certain gene. [6] [7]Congenital onychogryphosis of the fifth toe (the baby, little, pinky or small toe) is fairly common, but asymptomatic and seldom brought to the attention of medical professionals.
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