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The hippocampus is a structure in the brain that has been associated with various memory functions. It is part of the limbic system, and lies next to the medial temporal lobe. It is made up of two structures, the Ammon's Horn, and the Dentate gyrus, each containing different types of cells. [1]
The hallmark symptom of LATE is a progressive memory loss that predominantly affects short-term and episodic memory. [1] This impairment is often severe enough to interfere with daily functioning and usually remains the chief neurologic deficit, unlike other types of dementia in which non-memory cognitive domains and behavioral changes might be noted earlier or more prominently. [1]
It does not need to "reach out" to other brain structures for assistance in forming some memories of simple association. An MIT study found that behavior based on high-level cognition, such as the expression of a specific memory, can be generated in a mammal by highly specific physical activation of a specific small subpopulation of brain cells.
Hering and Semon developed general theories of memory, the latter inventing the idea of the engram and concomitant processes of engraphy and ecphory. Semon divided memory into genetic memory and central nervous memory. [7] This 19th-century view is not wholly dead, albeit that it stands in stark contrast to the ideas of neo-Darwinism. In modern ...
These mutations include changes in single DNA base pairs , insertions or deletions of DNA in the MECP2 gene, and changes that affect how the gene information is processed into a protein (RNA splicing). Mutations in the gene alter the structure of the MeCP2 protein or lead to reduced amounts of the protein.
Huntington's disease (HD) is a rare autosomal dominant neurodegenerative disorder caused by mutations in the huntingtin gene (HTT). HD is characterized by loss of medium spiny neurons and astrogliosis. [30] [31] [32] The first brain region to be substantially affected is the striatum, followed by degeneration of the frontal and temporal ...
Historically, questions regarding the functional architecture of the mind have been divided into two different theories of the nature of the faculties. The first can be characterized as a horizontal view because it refers to mental processes as if they are interactions between faculties such as memory, imagination, judgement, and perception, which are not domain specific (e.g., a judgement ...
Small-scale mutations affect a gene in one or a few nucleotides. (If only a single nucleotide is affected, they are called point mutations.) Small-scale mutations include: Insertions add one or more extra nucleotides into the DNA. They are usually caused by transposable elements, or errors during replication of repeating elements.