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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
Isotretinoin has also been linked to psychosis. [34] Many of the side effects of isotretinoin mimic hypervitaminosis A, which has been associated with psychotic symptoms. [57] The dopamine hypothesis of schizophrenia and psychosis suggests that an increase in dopaminergic stimulation or sensitivity in the limbic system causes psychotic symptoms ...
retinol, retinal, tretinoin (retinoic acid), isotretinoin, and alitretinoin: Second generation: Synthetic analogs formulated for oral dosing. There are no topically available second generation formulations of retinoids. etretinate and its metabolite acitretin: Third generation: Retinoidal benzoic acid derivatives: adapalene, bexarotene, and ...
Accutane Side Effects. Potential side effects of isotretinoin treatment can be aggravating, to say the least. According to the FDA (U.S. Food and Drug Administration), they include:
The name isotretinoin is the same root tretinoin plus the prefix iso-. Regarding pronunciation, the following variants apply equally to both tretinoin and isotretinoin. Given that retinoic is pronounced / ˌ r ɛ t ɪ ˈ n oʊ ɪ k /, [43] [44] [42] [45] it is natural that / ˌ t r ɛ t ɪ ˈ n oʊ ɪ n / is a commonly heard pronunciation.
Once a doctor decides a patient is a candidate for isotretinoin, [10] they counsel the patient to ensure they understand the drug and the potential side effects. Once the patient signs the necessary paperwork, their doctor will give them a patient ID number, ID card, and program educational materials.
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The exact cause is unknown. Mechanical, dietary factors and use of some medications (e.g. isotretinoin, etretinate, acitretin and other vitamin A derivatives) [9] may be of significance. There is a correlation between these factors but not a cause or effect.