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MDMA is an empathogenic-entactogenic and serotonergic psychotropic drug used primarily for recreational, though sometimes also therapeutic, purposes.Among users of MDMA, the serotonergic effects of the drug are often of particular interest and concern: After consuming MDMA, serotonin concentrations are greatly reduced in the brain. 5-HTP is necessary for serotonin production and its ...
The 5-HT 2C receptors are one of three subtypes that belong to the serotonin 5-HT 2 receptor subfamily along with 5-HT 2A and 5-HT 2B receptors. The development of 5-HT 2C agonists has been a major obstacle, because of severe side effects due to a lack of selectivity over 5-HT 2A and 5-HT 2B receptors.
5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]
Diabetes is very common. The Centers for Disease Control and Prevention (CDC) notes that 38.4 million people in the United States are currently living with diabetes. That’s 11.6 percent of the ...
5-HT receptors were split into two classes by John Gaddum and Picarelli when it was discovered that some of the serotonin-induced changes in the gut could be blocked by morphine, while the remainder of the response was inhibited by dibenzyline, leading to the naming of M and D receptors, respectively. 5-HT 2A is thought to correspond to what was originally described as D subtype of 5-HT ...
Image credits: Ludwig_Vista2 #7. Endometriosis (tissue from the womb) is not cancer. But it can send out cells that spread through your internal organs and grow, stick your guts together or block ...
Triptans should be taken as soon as possible after the onset of pain. In case of migraine with aura they are to be taken after the aura and with the onset of pain. [10] If taken too early, they may not have the full effect on symptom reduction, and in case of an aura, they can worsen the aura.
In the early days of insulin treatment for type 1 diabetes there was much debate as to whether strict control of hyperglycaemia would delay or prevent the long-term complications of diabetes. The work of Pirart [50] suggested that microvascular complications of diabetes were less likely to occur in individuals with better glycaemic control.