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In general, the higher your PSA level and the lower your free PSA level, the greater your risk of having prostate cancer. Ranges are determined by age.
Rather than subject everyone with an elevated PSA to a biopsy, some urologists measure free PSA in patients with a total PSA level between 4 ng/ml and 10 ng/ml. Studies have shown that men with a total PSA in this “gray area” and a free PSA greater than 25% are more likely to have a benign condition (=not harmful in effect) than to have cancer, ...
There are no normal levels of total PSA or free PSA for men of any age. Different doctors may use different cutoff points to decide if you need a biopsy or other further testing.
Free PSA ranges can vary, but generally, a higher ratio of free PSA to total PSA indicates a lower risk of prostate cancer. On the other hand, a low ratio of free PSA to total PSA...
PSA circulates in the blood in two forms — either attached to certain blood proteins or unattached (free). If you have a high PSA level but a low percentage of free PSA , it may be more likely that you have prostate cancer.
Generally speaking, though, PSA levels for men who are: Age 60 or older: should be at or below 4.0 mg/mL; Age 59 or younger: should be at or below 2.5 mg/mL; The average PSA for men in the younger group is <1.0 mg/mL. Why are my PSA levels elevated? Your PSA levels could be elevated for many reasons.
There is no specific normal or abnormal level of PSA in the blood. In the past, PSA levels of 4.0 ng/mL and lower were considered normal. However, some individuals with PSA levels below 4.0 ng/mL have prostate cancer and many with higher PSA levels between 4 and 10 ng/mL do not have prostate cancer (1).