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Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
An example of a bacteriophage known to follow the lysogenic cycle and the lytic cycle is the phage lambda of E. coli. [53] Sometimes prophages may provide benefits to the host bacterium while they are dormant by adding new functions to the bacterial genome , in a phenomenon called lysogenic conversion .
Bacteriophage therapy, commonly known as 'phage therapy,' uses bacteria-specific viruses to kill antibiotic resistant bacteria. Phage therapy offers considerably higher specificity as the phage can be engineered to only infect a certain bacteria species. [9] Phage therapy also allows for the possibility of biofilm penetration in cases where ...
Antibiotics are used both in treating human disease and in intensive farming to promote animal growth. Both uses may be contributing to the rapid development of antibiotic resistance in bacterial populations. [29] Phage therapy, using bacteriophages can also be used to treat certain bacterial infections. [30]
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
Transmission electron micrograph of multiple bacteriophages attached to a bacterial cell wall. A phageome is a community of bacteriophages and their metagenomes localized in a particular environment, similar to a microbiome. [1] [2] Phageome is a subcategory of virome, which is all of the viruses that are associated with a host or environment. [3]
In addition to combining one antibiotic with another, antibiotics are sometimes co-administered with resistance-modifying agents. For example, β-lactam antibiotics may be used in combination with β-lactamase inhibitors, such as clavulanic acid or sulbactam, when a patient is infected with a β-lactamase-producing strain of bacteria. [75]
An example of a virus that uses the lysogenic cycle to its advantage is the Herpes Simplex Virus. [10] After first entering the lytic cycle and infecting a human host, it enters the lysogenic cycle. This allows it to travel to the nervous system's sensory neurons and remain undetected for long periods of time.