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Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome, [4] Crohn's disease, and ulcerative colitis. [5]
By binding to μ-opioid receptors, loperamide inhibits acetylcholine release and decreases excitation of neurons in the myenteric plexus, which leads to a decrease in peristalsis. [4] Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating ...
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These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). [ 2 ] Mechanisms of peripheral selectivity include physicochemical hydrophilicity and large molecular size, which prevent drug permeation through the lipid bilayer cell membranes of the blood–brain barrier, and efflux out of the brain by ...
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Nearly half of all 3,100 counties in America have no doctors certified to prescribe buprenorphine by the Substance Abuse and Mental Health Services Administration and the Drug Enforcement Administration, according to a Huffington Post analysis. Hundreds of counties have very few certified doctors.
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It contains loperamide and simethicone. Loperamide is a μ-opioid receptor agonist that works in the intestines. [1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal ...