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Very common adverse effects of olanzapine, occurring more than 10%, include: Weight gain (dose-dependent). Weight gain of over 7% of a person's initial body weight prior to treatment is in this category of very common too with some estimates of its incidence putting it at around 40.6%.
Olanzapine is associated with weight gain, which according to recent studies, may put olanzapine-treated patients' offspring at a heightened risk for neural tube defects (e.g. spina bifida). [ 38 ] [ 39 ] Breastfeeding in women taking olanzapine is advised against because olanzapine is secreted in breast milk, with one study finding that the ...
Weight gain [18] There has been a study that suggests antipsychotics are associated with possible cortical reconfiguration and gray matter loss, [ 19 ] but correlational data also suggests patients who consume antipsychotics, like people with schizophrenia , tend to engage in unhealthy habits like smoking which may exacerbate gray matter loss.
In addition, the study was observational, meaning that it cannot prove cause, like that certain antidepressants cause weight gain or loss. Again, while researchers sought to focus on first-time ...
The typical adult gains an average of 1 to 2 pounds per year, which over time, can contribute to obesity. This weight gain can be driven by physical inactivity, stress, poor sleep and poor food ...
“Clinicians and patients can use this information, among other factors, to help decide on the right choice for them,” he added. Greatest risk of at least 5% weight gain at six months of use ...
In a meta-analysis of 18 antipsychotics, olanzapine and clozapine exhibited the worst metabolic parameters and aripiprazole, brexpiprazole, cariprazine, lurasidone, and ziprasidone the most benign parameters. [70] Aripiprazole, asenapine, ziprasidone and lurasidone have low propensity to cause weight gain. [71]
Weight gain (particularly prominent with clozapine, olanzapine, quetiapine and zotepine, [38] can be counteracted by starting the drug with metformin [125] [126]) Anticholinergic side-effects (common for olanzapine, clozapine; less likely on risperidone [127]) such as: Blurred vision; Constipation; Dry mouth (although hypersalivation may also ...