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The word zygosity may also be used to describe the genetic similarity or dissimilarity of twins. [6] Identical twins are monozygotic, meaning that they develop from one zygote that splits and forms two embryos. Fraternal twins are dizygotic because they develop from two separate oocytes (egg cells) that are fertilized by two separate sperm.
The human twin birth rate in the United States rose 76% from 1980 through 2009, from 9.4 to 16.7 twin sets (18.8 to 33.3 twins) per 1,000 births. [5] The Yoruba people have the highest rate of twinning in the world, at 45–50 twin sets (90–100 twins) per 1,000 live births, [6] [7] [8] possibly because of high consumption of a specific type of yam containing a natural phytoestrogen which may ...
The power of twin designs arises from the fact that twins may be either identical (monozygotic (MZ), i.e. developing from a single fertilized egg and therefore sharing all of their polymorphic alleles) or fraternal (dizygotic (DZ), i.e. developing from two fertilized eggs and therefore sharing on average 50% of their alleles, the same level of genetic similarity found in non-twin siblings).
Even monozygotic twins (who develop from one zygote) have infrequent genetic differences due to mutations occurring during development and gene copy-number variation. [1] Differences between individuals, even closely related individuals, are the key to techniques such as genetic fingerprinting .
Twin studies is an observational test using monozygotic twins and dizygotic twins, preferably same sex. They are used to figure out the environmental influence on complex traits. Monozygotic twins in particular are estimated to share 100% of their DNA with each other so any phenotypic differences should be caused by environmental influences. [2]
From twin studies is typically estimated at 0 because the correlation between monozygotic twins is at least twice the correlation for dizygotic twins. When using the Falconer variance decomposition ( 1.0 = a 2 + c 2 + e 2 {\displaystyle 1.0=a^{2}+c^{2}+e^{2}} ) this difference between monozygotic and dizygotic twin similarity results in an ...
One way to consider it is using trait X in twin 1 to predict trait Y in twin 2 for monozygotic and dizygotic twins (i.e. using twin 1's IQ to predict twin 2's brain volume); if this cross-correlation is larger for the more genetically-similar monozygotic twins than for the dizygotic twins, the similarity indicates that the traits are not ...
In 1982, twins who were born with two different skin colors were discovered to be conceived as a result of heteropaternal superfecundation. [7] [5] In 1995, a young woman gave birth to diamniotic monochorionic twins, who were originally assumed to be monozygotic twins until a paternity suit led to a DNA test. This led to the discovery that the ...