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  2. Dopamine hypothesis of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Dopamine_hypothesis_of...

    Psychopharmacologist Stephen M. Stahl suggested in a review of 2018 that in many cases of psychosis, including schizophrenia, three interconnected networks based on dopamine, serotonin, and glutamate - each on its own or in various combinations - contributed to an overexcitation of dopamine D2 receptors in the ventral striatum. [68]

  3. Glutamate hypothesis of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Glutamate_hypothesis_of...

    The glutamate hypothesis of schizophrenia models the subset of pathologic mechanisms of schizophrenia linked to glutamatergic signaling. The hypothesis was initially based on a set of clinical, neuropathological, and, later, genetic findings pointing at a hypofunction of glutamatergic signaling via NMDA receptors .

  4. Schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Schizophrenia

    Schizophrenia is a mental disorder [17] [7] characterized variously by hallucinations (typically, ... and dysregulating the dopamine and serotonin pathways. [99]

  5. Causes of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Causes_of_schizophrenia

    The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.

  6. Atypical antipsychotic - Wikipedia

    en.wikipedia.org/wiki/Atypical_antipsychotic

    The atypical antipsychotics integrate with the serotonin (5-HT), norepinephrine (α, β), and dopamine (DA) receptors in order to effectively treat schizophrenia. [84] D 2 Receptor: Hyperactive dopaminergic activity on D 2 receptors in the mesolimbic pathway is responsible for the positive symptoms of schizophrenia (hallucinations, delusions ...

  7. Management of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Management_of_schizophrenia

    Serotonin regulates executive function, sensory gating, and social behavior – all of which are commonly impaired in schizophrenia. The model proposed suggests that supplementation would help in preventing and treating these brain dysfunctions. [ 145 ]

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