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Intestinal glands are found in the epithelia of the small intestine, namely the duodenum, jejunum, and ileum, and in the large intestine (colon), where they are sometimes called colonic crypts. Intestinal glands of the small intestine contain a base of replicating stem cells, Paneth cells of the innate immune system, and goblet cells, which ...
Micrograph of the small intestine mucosa showing the intestinal villi and crypts of Lieberkühn. The three sections of the small intestine look similar to each other at a microscopic level, but there are some important differences. The parts of the intestine are as follows: This cross section diagram shows the 4 layers of the small intestine wall.
In human anatomy, the intestine (bowel or gut; Greek: éntera) is the segment of the gastrointestinal tract extending from the pyloric sphincter of the stomach to the anus and as in other mammals, consists of two segments: the small intestine and the large intestine.
The intestine is also called the bowel or the gut. The lower GI starts at the pyloric sphincter of the stomach and finishes at the anus. The small intestine is subdivided into the duodenum, the jejunum and the ileum. The cecum marks the division between the small and large intestine. The large intestine includes the rectum and anal canal. [2]
Paneth cells are found throughout the small intestine and the appendix at the base of the intestinal glands. [2] There is an increase in Paneth cell numbers towards the end of the small intestine. [3] Like the other epithelial cell lineages in the small intestine, Paneth cells originate at the stem cell region near the bottom of the gland. [4]
A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase its surface area. This facilitates transport of numerous small molecules into the enterocyte from the intestinal lumen. These include broken down proteins, fats, and sugars, as well as water, electrolytes, vitamins, and bile salts.
Colonic crypts deficient for CCOI in women reaches, on average, 18% in women and 23% in men by 80–84 years of age. [31] Crypts of the colon can reproduce by fission, as seen in panel C, where a crypt is fissioning to form two crypts, and in panel B where at least one crypt appears to be fissioning.
The barrier formed by the intestinal epithelium separates the external environment (the contents of the intestinal lumen) from the body [15] and is the most extensive and important mucosal surface of body. [18] The intestinal epithelium serves several crucial functions, exhibiting both innate and adaptive immune features.