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N,N-Diisopropylethylamine, or Hünig's base, is an organic compound that is a tertiary amine. It is named after the German chemist Siegfried Hünig [ de ] . It is used in organic chemistry as a non-nucleophilic base .
It is also used to prepare N,N-diisopropylethylamine (Hünig's base) by alkylation with diethyl sulfate. [ 8 ] The bromide salt of diisopropylamine, diisopropylammonium bromide, is a room-temperature organic ferroelectric material.
In the 1980s, the European Union began harmonising regulatory requirements. In 1989, Europe, Japan, and the United States began creating plans for harmonisation. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) was created in April 1990 at a meeting in Brussels.
HATU was first reported by Louis A. Carpino in 1993 as an efficient means of preparing active esters derived from 1-hydroxy-7-azabenzotriazole (HOAt). [2] HATU is commonly prepared from HOAt and TCFH under basic conditions [3] and can exist as either the uronium salt (O-form) or the less reactive iminium salt (N-form).
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Inhalation and skin contact are expected to be the primary ways of occupational exposure to this chemical. Based on single exposure animal tests, it is considered to be slightly toxic if swallowed or inhaled, moderately toxic if absorbed through skin as well as being corrosive to eyes and skin. [1]
N,N-Diisopropylethylamine, or Hünig's base; Octodrine; Oenethyl This page was last edited on 17 January 2025, at 01:53 ...