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For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the patient from 40 mg of morphine to 10 mg of levorphanol would be dangerous due to dose accumulation, and hence frequency of administration should also be taken into account.
At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose. The concentration-time profiles of the ( R )-(−)-enantiomer following a single dose of 50 mg Nuvigil or 100 mg Provigil (modafinil being a 1:1 mixture of ( R )-(−)- and ( S )-(−)- enantiomers) are nearly superimposable.
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
[3] [2] [4] The modafinil analogues are of interest in the potential treatment of a condition involving the misuse of stimulant drugs (psychostimulant use disorder or PSUD), as drugs that help increase motivation (pro-motivational agents) to treat motivational disorders, [4] [5] [6] and for treatment of neurodegenerative diseases such as ...
The pharmaceutical company Cephalon, the original United States market rights holder of modafinil, has demonstrated initiative in the development of a successor to the prototypical eugeroic. [25]
The clinic also spent nearly $100,000 during that period on Provigil, a stimulant that is “55 times more expensive than the generic equivalent,” the report said. In 2019, investigators tried ...
Provigil Nevirapine [citation needed] Norfloxacin [14] Oseltamivir [citation needed] Oxicams [7] Ampiroxicam, Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam, Isoxicam: Paracetamol [15] [16] Acetaminophen, Panadol, Tylenol Penicillins [5] Phenytoin [5] Rivoraxaban [17] Xarelto: Sitagliptin [citation needed] Sulfonamides [2] Tetracycline [2
Stelazine (trifluoperazine) – an antipsychotic used in the treatment of psychotic disorders, anxiety, and nausea caused by chemotherapy [2] Strattera (atomoxetine) – a non-stimulant medication used to treat ADHD; Suboxone (buprenorphine/naloxone) - a partial opioid agonist used in the treatment of opioid use disorder
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