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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
In April 2021, the developers announced plans to launch a Kickstarter project later in the month to turn the demo into a full game. [12] On April 18, a Kickstarter project for the full version of the game was released under the name Friday Night Funkin': The Full Ass Game and reached its goal of $60,000 within hours. [18]
Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [8]
ATC code B01 Antithrombotic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
FnF, a Bangladeshi drama "F.N.F. (Let's Go)", a 2022 song by Hitkidd and GloRilla; Friday Night Fights, an American boxing television series; Friday Night Funkin', a 2020 rhythm-based video game; Fresh and Fit Podcast, male self-improvement podcast hosted by Myron Gaines and Walter Weekes, also known as FnF Podcast
The following other wikis use this file: Usage on ar.wikipedia.org أبيكسابان; Usage on el.wikipedia.org Απιξαμπάνη; Usage on es.wikipedia.org