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53335 14025 Ensembl ENSG00000119866 ENSMUSG00000000861 UniProt Q9H165 Q9QYE3 RefSeq (mRNA) NM_018014 NM_022893 NM_138553 NM_138559 NM_001363864 NM_001365609 NM_001159289 NM_001159290 NM_001242934 NM_016707 RefSeq (protein) NP_060484 NP_075044 NP_612569 NP_001350793 NP_001352538 NP_001152761 NP_001152762 NP_001229863 NP_057916 Location (UCSC) Chr 2: 60.45 – 60.55 Mb Chr 11: 24.08 – 24.17 Mb ...
A locus control region (LCR) is a long-range cis-regulatory element that enhances expression of linked genes at distal chromatin sites. It functions in a copy number-dependent manner and is tissue-specific, as seen in the selective expression of β-globin genes in erythroid cells. [1]
Enhanceosomes are formed in special cases when these activators cooperatively bind together along the enhancer sequence to create a distinct three-dimensional structure. Each enhanceosome is unique towards its specific enhancer. This assembly is facilitated by energetically favorable protein: protein and protein: DNA interactions. Therefore ...
Thus, it was able to create a map of candidate enhancers controlling specific genes. The data obtained were validated with the chromosome conformation capture carbon copy (5C) technique. This technique is based in the physical association that exists between the promoter and the enhancers, determining the regions of chromatin that enter in ...
Many CRMs have been mapped within the cluster of genes encoding β-like globins expressed in embryonic (HBE1), fetal (HBG1 and HBG2), and adult (HBB and HBD) erythroid cells. All are marked by DNase I hypersensitive sites and footprints , and many are bound by GATA1 in peripheral blood derived erythroblasts (PBDEs).
Several cell function specific transcription factor proteins (in 2018 Lambert et al. indicated there were about 1,600 transcription factors in a human cell [8]) generally bind to specific motifs on an enhancer [9] and a small combination of these enhancer-bound transcription factors, when brought close to a promoter by a DNA loop, govern the ...
In the field of molecular biology, the ETS (E26 transformation-specific [2] or Erythroblast Transformation Specific [3]) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila.
B-cell CLL/lymphoma refers to a family of genes associated with certain types of lymphoma and leukemia.. Although named for B-cell chronic lymphocytic leukemia, they can be associated with other malignancies.
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