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Midodrine, sold under the brand names ProAmatine and Orvaten among others, is a vasopressor or antihypotensive medication used to treat orthostatic hypotension (low blood pressure when standing) and urinary incontinence. [3] [5] [1] It is taken by mouth. [3] [1]
The medication midodrine, an α 1-adrenergic receptor agonist, can benefit people with orthostatic hypotension, [33] [35] The main side effect is piloerection ("goose bumps"). [35] Fludrocortisone is also used, although based on more limited evidence.
A systematic review and meta-analysis conducted on clinical trials comparing the clinical use of droxidopa and midodrine have found that midodrine was more likely to cause supine hypertension than droxidopa in patients with NOH. Midodrine was also found to be slightly more effective at raising blood pressure but not statistically significantly ...
[2] [4] If this is insufficient for treating vasovagal syncope, medications such as midodrine or fludrocortisone may be tried. [4] Occasionally, a cardiac pacemaker may be used as treatment. [2] Reflex syncope affects at least 1 in 1,000 people per year. [1] It is the most common type of syncope, making up more than 50% of all cases. [2]
Orthostatic syncope refers to syncope resulting from a postural decrease in blood pressure, termed orthostatic hypotension. [1]Orthostatic hypotension occurs when there is a persistent reduction in blood pressure of at least 20mmHg systolic or 10mmHg diastolic within three minutes of standing or being upright to 60 degrees on the head-up tilt table.
Desglymidodrine (developmental code name ST-1059) is the active metabolite of the prodrug antihypotensive agent midodrine. [1] [2] [3] It acts as a selective α 1-adrenergic receptor agonist. [1] [2] [3] Desglymidodrine is formed from midodrine via deglycination. [1] [2] [3]
[1] [2] [3] It is assumed to be a manifestation of disorders of the autonomic nervous system [4] or due to side effects of medications such as midodrine and droxidopa. [ 5 ] [ 6 ] References
Hypotension, also known as low blood pressure, is a cardiovascular condition characterized by abnormally reduced blood pressure. [1] Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood [2] and is indicated by two numbers, the systolic blood pressure (the top number) and the diastolic blood pressure (the bottom number), which are the ...