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Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. [8] It is taken by mouth. [8] Temazepam is rapidly absorbed, and significant hypnotic and anxiolytic effects begin in less than 30 minutes and can last for up to eight hours.
Flutemazepam was initially first synthesized in 1965, [1] but was not further described until a team at Stabilimenti Chimici Farmaceutici Riuniti SpA in the mid-1970s. [2] [3] It is a short-acting (9–25 hr elimination half-life) fluorinated analogue of temazepam that has powerful hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties.
As of November 2012, medications approved as no-go pills by the U.S. Air Force for aircrew and AFSOC [1] forces include: Temazepam (Restoril), with a 12-hour restriction on subsequent flight operation; Zaleplon (Sonata), with a 4-hour restriction on subsequent flight operation; Zolpidem (Ambien), with a 6-hour restriction on subsequent flight ...
A prescription is needed for possession of all benzodiazepines. Temazepam formulations containing 20 mg or greater of the drug are placed on List 1, thus requiring doctors to write prescriptions in the List 1 format. [211] In East Asia and Southeast Asia, temazepam and nimetazepam are often heavily controlled and restricted.
It is the dimethyl carbamate ester of temazepam, a metabolite of diazepam. [3] While it possesses anxiolytic , anticonvulsant , skeletal muscle relaxant and hypnotic properties [ 4 ] it differs from other benzodiazepines in that its anxiolytic properties are particularly prominent but has comparatively limited anticonvulsant , hypnotic and ...
Half maximal effective concentration (EC 50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. [1] More simply, EC 50 can be defined as the concentration required to obtain a 50% [...] effect [2] and may be also written ...
Lormetazepam, sold under the brand name Noctamid among others, is a drug which is a short to intermediate acting 3-hydroxy [3] benzodiazepine derivative and temazepam analogue. [4] It possesses hypnotic , anxiolytic , anticonvulsant , sedative , and skeletal muscle relaxant properties.
Oxazepam is an intermediate-acting benzodiazepine with a slow onset of action, [14] so it is usually prescribed to individuals who have trouble staying asleep, rather than falling asleep. It is commonly prescribed for anxiety disorders with associated tension, irritability, and agitation.