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Langhans giant cells (LGC) are giant cells found in granulomatous conditions. They are formed by the fusion of epithelioid cells ( macrophages ), and contain nuclei arranged in a horseshoe-shaped pattern in the cell periphery.
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.
Langerhans cell is represented by a yellow oval; blue arrows correspond to is_a relations, and orange arrows correspond to develops_from relations. Only a subset of Langerhans cell parent types are included in the figure. [1] A Langerhans cell (LC) is a tissue-resident macrophage of the skin [2] once thought to be a resident dendritic cell. [3]
Granuloma with central necrosis in a lung of a person with tuberculosis: Note the Langhans-type giant cells (with many nuclei arranged in a horseshoe-like pattern at the edge of the cell) around the periphery of the granuloma. Langhans-type giant cells are seen in many types of granulomas and are not specific for tuberculosis.
Fragment of the outer edge zone of tuberculosis epithelioid cell granuloma. In the lower part – a layer of epithelioid cells, in which Langhans giant cell begins to form, as a result of the fusion of epithelioid cells. In it, we can notice the division of the cell nucleus of epithelioid cells, from which smaller nucleus are formed.
A foreign-body giant cell is a collection of fused macrophages which are generated in response to the presence of a large foreign body. This is particularly evident with catheters , parasites , or biomaterials that are inserted into the body for replacement or regeneration of diseased or damaged tissues.
"Cytotrophoblast" is the name given to both the inner layer of the trophoblast (also called layer of Langhans) or the cells that live there. It is interior to the syncytiotrophoblast and external to the wall of the blastocyst in a developing embryo.
Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Symptoms range from isolated bone lesions to multisystem disease . [ 1 ]